Release Announcement – Signals Screening Professional

May 29, 2018

PerkinElmer Informatics is pleased to announce the release of Signals Screening Professional, which has been qualified to be compatible with Spotfire 7.10 and 7.11 LTS.

Signals Screening Professional enables biologists to perform all the foundational steps of screening:

· Load data from instruments. Signals Screening brings the power of the SciStream instrument file parser to the screening scientist and ties it more directly into the data processing workflow.
· Develop and reuse plate maps. A key part of the screening process is the definition of the layout of the test articles on a plate. Signals Screening provides an easy, point-and-click plate map builder and easy options for plate map storage and reuse.
· Normalize the data with standard or customer-defined methods. We provide out-of-the-box the most standard normalization methods and customers can easily define their own normalization equations in an intuitive interface.
· Define and review Curve Fits. Any measurement from the plate and be selected for input into a parameterized and customizable curve fit engine, and the resulting curves can be reviewed and adjusted by knocking out aberrant points.
· Publish the results to Signals Lead Discovery. As a final step, a processed dataset can be published to Signals Lead Discovery to be used by the lead discovery scientist in deciding which candidates to advance.
· Protocol authoring and reuse. The whole user-defined workflow can then be saved to Signals Screening so routine assays can be run and data processed in an efficient and repeatable fashion.

Also, for the first time ever, Signals Screening Professional enables the full processing of SPR data from instrument through normalization to results. Surface Plasmon Resonance (SPR) allows the research team to study both affinity and specificity of the binding antibody-antigen interaction and perform kinetic studies of association and dissociation rates in real time, providing direct information about binding events at the sensor surface.

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